Lediga jobb Spatial Transcriptomics AB i Stockholm

About the role:
We are looking for an outstanding individual to join our Molecular Biology team as an Intern - Scientist.
The ideal candidate will have a proven track record in the development, optimization, and application of molecular biology techniques for solving complex biological problems, especially in the broad field of immunology and/or tumor biology.
Using your experience, you will ensure that our new products are compatible with relevant biological sample types and designing optimized workflows for product use. You will work with a cross-disciplinary team of biologists and chemists, as well as colleagues in computational biology, software, manufacturing, and marketing from all across the company. Beyond the technical qualifications, you must be highly goal-oriented, inquisitive, organized, independent, collaborative, willing to learn new techniques and concepts and be able to thrive in an atmosphere of shifting demands and priorities.
What you will be doing:
Contribute to the development and optimization of sample preparation procedures for spatial genomic and proteomic assays that yield fundamental improvements in data quality
Planning and execution of experiments, in-depth analysis, and reporting of thorough documentation and presentations
Plan and perform systematic workflow and reagent optimization by modeling, identification of critical factors and use of formal design of experiment (DOE) approaches
Work closely with computational biologists to interpret data generated by novel and optimized assay schemes
Contribute molecular biology and immunology expertise to cross-disciplinary product development teams to ensure project milestones are met, product performs to specifications

Minimum Qualifications:
A Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Immunology, or similar
Meticulous attention to detail and strong record keeping skills
Experience with next generation sequencing sequencing library preparation workflows and data interpretation.
Strong troubleshooting and problem solving skills
Ability to analyze and interpret complex datasets and communicate results in a clear and concise manner
Demonstrated ability to work in a multi-disciplinary team
Desire to build game-changing technologies and impact the world of immunology and life science research in a fast-paced and quickly changing environment

Preferred Skills and Background:
Experience with tissue processing, histology, immunohistochemistry, cryosectioning, immunofluorescence including characterization by surface markers or gene expression
Familiarity with Flow cytometry, Mass cytometry and/or multi-plexing spatial protein assays
Experience with fluorescent in situ hybridization techniques (e.g. smFISH)
Experience in next-generation sequencing and/or in-situ sequencing
Experience working with antibodies, including mAb QC, conjugation, functional testing
Experience in interpreting the biological findings from an experiment and understanding what impact they may have
Proficiency in standard molecular biology techniques

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As the Chemistry Scientist for 10xGenomics you are an exceptional scientist with a strong background in oligonucleotide chemistry to drive the new research and product development efforts at our Stockholm R&D facility, with an emphasis on spatial genomics.
You have a degree in chemistry, a broad understanding of next generation sequencing, and a proven track-record of developing novel molecular biology assays for solving complex biological problems. You are driven by making great products and enjoy working in a truly multi-disciplinary environment.
You will be working within a great team of about 25 people in Stockholm which continues to grow rapidly. Everybody is motivated to work together for researching and developing the next generation of in situ analysis technology in a highly interdisciplinary environment.
Key Responsibilities:
Conceive and develop novel assay schemes for use of 10x Genomics technology platforms, with emphasis on spatial transcriptomics and in situ assays.
Plan and perform systematic workflow and reagent optimization by modeling, identification of limiting steps and use of formal design of experiment (DOE) approaches.
Contribute biochemistry expertise and leadership to cross-disciplinary product development teams.
Work closely with computational biologists to interpret data generated by novel and optimized assay schemes.
Work closely with process development staff to develop quality control and manufacturing strategies for novel or optimized reagents.
Required Skills and Background:
PhD in chemistry, biochemistry or a related field with a minimum of 1 year post-graduate experience in academia and/or industry.
Extensive knowledge of oligonucleotide and nucleotide modifications and their biological properties
Demonstrated ability to design, synthesize, purify, and characterize oligonucleotides and related novel compounds.
Strong organizational skills, interpersonal skills, including written and oral communication.
Ability to work in a fast-paced and quickly changing environment.
A strong desire to build game-changing technologies and impact the world of life science research
Desired Skills and Background:
Strong background in molecular biology and proven ability to design novel molecular biology assay schemes, as evidenced by peer-reviewed publications, published patents or launched products.
Experience developing high-throughput assays based on next generation sequencing.
Experience in spatial transcriptomics, in situ RNA or protein assays or other technologies for analysis of complex tissues.
Experience in single-cell genomics, functional genomics or immunology.
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About the role:
‘In Situ’ is the “new” buzzword in Spatial Biology research. In situ analysis of hundreds of genes in all individual cells within intact tissue samples is going to be a major game changer for biology research, medicine and the future of diagnostics.
Our R&D team in Stockholm, Sweden:
You will be working within a great team of about 25 people in Stockholm which continues to grow rapidly. Everybody is motivated to work together for researching and developing the next generation of in situ analysis technology in a highly interdisciplinary environment.
In this position you will be part of a team responsible for researching and developing the next generation of in situ analysis chemistry in a highly interdisciplinary environment. This work will be in close collaboration with expert scientists within spatial single cell analysis and gives you the possibility to participate in high profile cutting edge biological and disease-related research projects
What you will be doing:
? Help with the design and develop of new in situ analysis methodology and decoding chemistry
? Work in a highly interdisciplinary environment focused on developing in situ decoding chemistry
? Library preparation and in situ analysis of different biological and clinical samples Fluorescence microscopy and image data processing
? Help with designing oligonucleotide sequences, testing and tuning their performance
? Support downstream analysis of in situ data
? Development and improvement of the ISS pipeline
To be successful, you will need:
? MSc, or equivalent, in Biomedical sciences / Molecular Biology, Biochemistry or Biophysics
? Wetlab experience with immune-staining and/or in situ hybridization techniques on tissue sections
? Fluorescent microscopy experience
? Experience in a wide range of Molecular Biology techniques
? Experience in primer/probe oligonucleotide sequence design
? Manage technical challenges independently
? To be able to work in an interdisciplinary environment
? Excellent written and spoken communication skills (English)
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We are looking for an outstanding individual to lead and grow our Computational Biology team in Stockholm, Sweden.
The ideal candidate will have a proven track record of leading and developing teams of data scientists that have successfully developed robust methods or products using molecular-based technologies.
The candidate must combine impressive technical leadership, excellence in people management, and a strong drive for making great products. You thrive in a fast paced environment, excel at managing multiple priorities, communicate clearly and get the job done. This position will interact closely with R&D leadership both in Stockholm and Pleasanton HQ.
In addition to leading the computational team, the successful candidate will work closely with talented biochemists, microfluidics engineers, chemists and software engineers to develop methods for single-cell and spatial genomic assays. You will innovate computational methods and analyses to improve product performance during a fast-paced product development cycle. This includes deep-dive analysis of cutting-edge in-house R&D and collaborator datasets, algorithm analysis & prototyping, implementation of new features, and improving the functionality of 10x’s software solutions.
The ideal candidate will be interested in method development for single cell and spatial genomics, drawing on training in statistics, optimization, graph algorithms, text algorithms, and beyond. You are a good programmer who can take an idea and quickly implement it in code. Any prior experience combining novel and existing tools into effective pipelines is a plus.
What you will be doing:
Lead the Computational Biology team in Stockholm working on product and software development
Recruit top talent to build out the Stockholm Comp Bio team across multiple technical areas
Provide technical guidance and insights to group members on challenging problems
Develop analysis tools to measure and guide development of genomic assays
Use exploratory analysis and statistical models to troubleshoot and optimize genomic assays
Build statistical analyses into robust tools for monitoring assay performance over time
Define experimental metrics for measuring assay quality, and determining goals & priorities for assay development work
Design proof-of-concept experiments, analyzing and interpreting the data to demonstrate the unique power of the 10x Genomics platform internally and externally



To be successful in this role, you will need:
PhD plus equivalent experience in a quantitative field (e.g. physics, mathematics, computer science, electrical engineering, computational/systems biology or related field)
Strong leadership and organizational skills
Experience managing teams (>5) of data scientists
Attract, develop and retain diverse talent
Ability to quickly conceive and implement custom statistical methods and algorithms and apply them to large data sets
Ability to use Python and R in method development and data analysis
Ability to work in a highly matrixed, fast-paced and quickly changing environment
Ability to communicate complex ideas with an interdisciplinary team
Demonstrable experience with the analysis of NGS data
A strong desire to build game-changing technologies and impact the world of life science research

Additional, desirable, skills & experience:
A deep intuition for the processes utilized by current NGS technologies and the subtleties of NGS data
Creative problem solver who obsesses over finding useful information in data
Hands on experience with NGS data tools (e.g. bwa, samtools, GATK)
Experience analyzing multiplexed imaging datasets (e.g. in situ sequencing, multiplexed FISH)
A combination of mathematical depth with a healthy respect for the imperfections inherent in real-world data
Exhibits focus; appropriately prioritizes, manages expectations and delivers on commitments



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As a local IT Support Engineer you will be working within a R&D facility, including BSL1 and BSL2 clean rooms.
This is a stand-alone role that forms part of a larger global IT Team. Within the role you'll be utilizing your extensive knowledge of both Windows and macOS, leveraging your previous experience and existing skills in end-user support. This is an extremely fast-paced environment so you'll need to be highly organized, possess excellent communication and customer service skills, enjoy working with end-users daily, and have the ability to operate efficiently in a fast-paced environment.
Information technology is a vital and integral part of our success. At 10x, IT not only provides secure, stable, and scalable infrastructure and services for the business, it serves as a catalyst for innovation and productivity.
What you will be doing:
Configure, deploy, and support desktops, laptops, and other end-user devices.
Manage user accounts, security groups, mailing lists, and application access according to SOPs.
Handle service requests, troubleshoot and resolve issues in a thorough, timely and professional manner.
Assist in the testing and deployment of new technologies.
Maintain detailed documentation, change records, and inventory.
Support and maintain audio/visual and VoIP software and devices.
Off-hour support may be required on occasions.



To be successful in this role, you will need:
Bachelor’s degree in IT-related field or equivalent work experience.
multi-year experience configuring and supporting Microsoft Windows and Apple macOS.
Experience with Mobile Device Management technologies.
Experience in managing user accounts, security groups, and group policies in Active Directory.
Experience with endpoint protection and backup software.
Experience in configuring and troubleshooting collaboration and productivity software including Gmail, GWSMO, Microsoft Office, Adobe Acrobat, and Outlook.
Solid understanding of basic networking and security concepts such as DNS, DHCP, SSL, VPN, and encryption.
Experience with supporting VoIP and audio/visual systems.
Must be detail oriented, organized, and able to multi-task, with a commitment to resolve issues and complete projects and tasks in a responsive, accurate, and timely manner.
Excellent written and verbal communication skills. Ability to clearly explain IT concepts to both technical and non-technical users.



Additional, desirable, skills & experience:
Strong understanding of administering Active Directory servers and print servers.
Experience with Mobile Device Management: MS InTune, JAMF, MobileIron endpoint management
Extensive experience in Google G-Suite Business/Enterprise Administration
Basic knowledge Azure Active Directory Cloud, LDAP, Networking protocols
Extensive experience in site expansion dealing with build outs for AV and IT
Strong experience in GDPR compliance specific to EMEA a plus
Experience in BSL1 and BSL2 clean rooms



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You will be responsible for performing analysis of ISS data from customer projects and to support technical and data/image related questions. The tasks might extend over time to a broader responsibility of being the owner of delivering these projects. You will also contribute to further improve and develop image analysis pipeline. This position runs in close collaboration with a team of qualified scientists with expertise on image acquisition, image analysis and statistical analysis of ISS data. During this you will be exposed to high profile cutting edge biological and disease-related research projects from Pharma- and academic customers.
What you will be doing:
Large-volume microscopy image data processing and analysis
Performance and delivery of ISS analysis in a structured, efficient and documented way
Cell identification (e.g. via standard image segmentation or machine-learning approaches)
Provide downstream support for end users



To be successful, you will need:
MSc in computer science / engineering / bioinformatics or other relevant education
Image analysis experience (e.g. CellProfiler, ImageJ)
Programming languages: experienced in Python or MATLAB
Excellent written and spoken communication (English is our working language) and problem-solving skills
Experience interacting with a team of scientists, and a publication track record with collaborators





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As a Facilities Manager you will help to support 10x’s Spatial Transcriptomics facility in Stockholm as well as oversee other offices the region and future expansions. Critically, you will be supporting the combining of two sites in Stockholm into one location.
Based in Stockholm and reporting to 10x’s global headquarters in Pleasanton, CA, with a matrix reporting relationship to the leader of the Stockholm R&D.
What you will be doing:
Manage support of R&D labs and office areas. Ensure that all labs and critical facilities are maintained at a high level, minimizing down-time. This includes all building services (e.g. HVAC, elevators, technical custodial service)
Manage systems to maintain air conditioning and heating levels at a comfortable and accurate level for people and lab space, working with property management as appropriate
Direct contractors in electrical, mechanical and plumbing installations
Ensure proper maintenance of 10x’s facilities infrastructure and MEP assets, leveraging available systems
Liaison with property management in their responsibility for building systems upkeep, confirming that they provide the contracted services
Work with Purchasing to negotiate contracts for facilities vendors (e.g. HVAC, compressors), balancing great service levels with competitive pricing
Purchase furniture, fixtures and equipment for office and labs spaces as needed
Develop and manage operating and capex budgets
Collaborate with Stockholm R&D leaders and lab manager to ensure alignment on priorities and required support for the site
Coordinate closely with Stockholm R&D Lab Operations Manager, ensuring that R&D’s needs are address and providing facilities related support
Under the guidance of 10x’s EH&S Manager and working with the R&D Lab Operations Manager, act as on-site liaison for health and safety, following regulatory protocols, addressing deficiencies as needed
Ensure workplace safety precautions are communicated to employees as needed
Coordinating with 10x’s Security Manager, ensure that corporate programs and processes are implemented in the region
Coordinating with 10x’s Workplace Manager, ensuring global standards are met with in the workplace
Support facilities capital projects including labs and coordinate with the Workplace Manager for office areas
Organize / move light furniture and fixtures



To be successful, you will need:
Demonstrated, multi-year, facilities management experience in a biotech or life science facility
Outstanding organizational, interpersonal, written and verbal communication skills, with the ability to influence at all levels
Collaborative approach with the team and suppliers
Ability to handle multiple requests, work in a fast-paced environment, and be responsive to employee requests/service issues
Ability to bring creative, nonstandard, and innovative solutions to the table.
Ability to examine data and draw business conclusions
Excellent analytical and problem-solving skills
Proficient in Microsoft office and Google Suite
Fluent English and Swedish language skills (both written and spoken)


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Collaborate with expert scientists within spatial single cell analysis
About the role:
In this position you will be part of a team responsible for preparing and processing biological tissue samples through our in-situ sequencing (ISS) pipeline. You will support all aspects of the process including upstream bioinformatics to data analysis to ensure highest quality of results are reached. This work will be in close collaboration with expert scientists within spatial single cell analysis and gives you the possibility to participate in high profile cutting edge biological and disease-related research projects.
What you will be doing:
Project management including sample handling, probe design, and communication with relevant functions within the projects
Library preparation and ISS of biological samples on microscope glass slides
Fluorescent microscopy imaging and data processing
Support downstream analysis of ISS data
Development and improvement of the ISS pipeline

To be successful, you will need:
Minimum MSc, or equivalent, in Biomedical sciences / bioinformatics
Wetlab experience with immune-staining and/or in situ hybridization techniques on tissue sections
Fluorescent microscopy experience (confocal or standard epi-fluorescence)
Large scale image analysis using relevant SW (e.g. CellProfiler, ImageJ)
Experience of designing probes for targeted enrichment/assays
Excellent problem-solving skills
Written and spoken communication skills (English)

It would be advantageous if you had:
Academic degree (PhD, MSc, BSc) in computer science / engineering
Programming languages: experienced in Python or MATLAB, or other is a plus



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